Research Assistant II – Translational Molecular Pathology – MD Anderson Cancer Center – Houston, TX

MD Anderson Cancer Center

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Full Job Description

The primary purpose of the Research Assistant II position is to carry out laboratory bench work in research projects at TMP -IL Imaging Lab using novel High-plex staining and imaging methodologies, manually and with automated systems including the GeoMX Digital Spatial Profiler (DSP). The RAII will focus on the cancer immunoprofiling studies under the MOSAIC program. MOSAIC is dedicated to collecting, integrating, managing and enriching the combined data and samples from at least 10,000 cancer patients at MD Anderson. Patient Mosaic will lead to the development of better insights for improving health outcomes for individual patients and, more broadly, all patients with cance. The RAII must be able to provide technical and coordination skills to carry out the research projects, coordinate and support procedures, and perform technical laboratory duties in accordance with general and/or specific plans.


Caring Behaviors
  • Courtesy: Is respectful and courteous to each other at all times.
  • Friendliness/Teamwork: Promotes and rewards teamwork and inclusiveness; is sensitive to the concerns of our patients and our co-workers.

Integrity Behaviors
  • Reliability: Communicates frequently, honestly and openly.
  • Accountability: Holds self and others accountable for practicing our values.
  • Safety: Models safe behavior (wears badge and personal protective equipment, washes hands, and keeps work area clean and orderly); Notices a safety concern or emergency, understands role and uses proper procedures to report it; Mitigates risk to the institution through sound business practices; Demonstrates ethical and personal responsibility in work and behavior

Discovery Behaviors
  • Responsiveness: By his/her actions, creates an environment of trust; Encourages learning, creativity and new ideas.
  • Personal Leadership/Self-Initiative: Helps others to identify and solve problems; Seeks personal growth and enables others to do so.


Operate and Support Multiplexed Imaging Technologies using Ion beams, oligo barcoding, immunofluorescence, and immunohistochemistry staining.
Such as – Tyramide signal amplification methodology (Opal workflow, Akoya Biosciences), and other techniques as chromogenic IHC for immune profiling tumor tissues. Perform validation, optimization, troubleshooting staining of antibodies and panels using these novel techniques (MIBI and CODEX systems). Utilize laboratory equipment to carry out those procedures. Learn and perform Multiplex immunofluorescence technique.

Data gathering and Analysis Record and organization of data in accordance with methods requested. Operate scanner systems involved in the different methodologies related to the imaging techniques for digital pathology analysis and troubleshoot small technical problems when detected.

Develop novel imaging staining procedures for immune profiling and biomarkers discovery. Develop immunohistochemistry based techniques utilizing Formalin Fixed Paraffin Embedded (FFPE) surgical specimens and Core Needle Biopsies from different tumor types for immune profiling and biomarkers discovery. Perform research, update, and upgrade for those high plex imaging and staining methodologies for complex research projects involving immune profiling. Works under supervision of faculty and laboratory members to optimize workflows panels for those techniques.

Laboratory Maintenance Maintains Lab Functions to include tracking the inventory of samples, reagents and ensures lab equipment is maintained in good operating order.

Other duties as assigned

Bachelor’s degree with major course works in one of the basic sciences. Two years experience in scientific or experimental research work. No experience required with preferred degree. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.

Additional Information
  • Requisition ID: 145486
  • Employment Status: Full-Time
  • Employee Status: Regular
  • FLSA: exempt and not eligible for overtime pay
  • Work Week: Days
  • Fund Type: Soft
  • Remote Work: Hybrid Onsite/Remote
  • Pivotal Position: Yes
  • Minimum Salary: US Dollar (USD) 36,000
  • Midpoint Salary: US Dollar (USD) 44,500
  • Maximum Salary : US Dollar (USD) 54,000
  • Science Jobs: No


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