BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Pathology News - ECPv6.16.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Pathology News
X-ORIGINAL-URL:https://www.pathologynews.com
X-WR-CALDESC:Events for Pathology News
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:UTC
BEGIN:STANDARD
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
TZNAME:UTC
DTSTART:20250101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:20251026T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:20261025T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:20270328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:20271031T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=UTC:20260119T140000
DTEND;TZID=UTC:20260119T150000
DTSTAMP:20260829T200110
CREATED:20260107T121138Z
LAST-MODIFIED:20260107T121138Z
UID:100117733-1768831200-1768834800@www.pathologynews.com
SUMMARY:TIA Centre Seminar Series – Do androids dream of digital diagnoses? A pathologist’s perspective on digital and computational pathology.
DESCRIPTION:The Tissue Image Analytics (TIA) Centre hosts a seminar series for those interested in computational pathology. The series invites researchers and leaders in computational pathology and related fields to present their work and foster thought-provoking discussions. \nThis seminar features Dr Diana Montezuma Felizardo from IMP Diagnostics\, Portugal. \nAbstract\nWith a nod to Do androids dream of electric sheep? this talk will explore digital and computational pathology from a pathologist’s point of view. This session aims to be very practical\, bringing together a pot pourri of insights from real-world digital deployment and hands-on experience with computational research projects. The goal is to demystify the digital transition\, highlight pathologists’ contributions to CPath projects\, and emphasise the importance of multidisciplinarity in CPath research. \nRegister NowBio\nPathologist\, currently coordinating the R&D Unit at IMP Diagnostics (Portugal); invited junior researcher at the Cancer Biology and Epigenetics Group (CBEG) – Portuguese Institute of Oncology of Porto; board member and chair of the Scientific Committee of the European Society of Digital and Integrative Pathology (ESDIP). Medical degree from University of Coimbra (FMUC); PhD in Medical Sciences from ICBAS\, University of Porto.
URL:https://www.pathologynews.com/event/tia-centre-seminar-series-do-androids-dream-of-digital-diagnoses-a-pathologists-perspective-on-digital-and-computational-pathology/
LOCATION:Online
CATEGORIES:Live Online Webinar
ATTACH;FMTTYPE=image/png:https://www.pathologynews.com/wp-content/uploads/2026/01/TIA-Centre-Seminar-Series-–-Do-androids-dream-of-digital-diagnoses-A-pathologists-perspective-on-digital-and-computational-pathology.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/London:20260122T160000
DTEND;TZID=Europe/London:20260122T170000
DTSTAMP:20260829T200110
CREATED:20251212T110900Z
LAST-MODIFIED:20251212T110900Z
UID:100117398-1769097600-1769101200@www.pathologynews.com
SUMMARY:Highly Multiplexed Imaging Reveals CAF-immune Cell Niches in Cutaneous Carcinomas
DESCRIPTION:0000Days00Hrs00Min00SecRegister below! The webinar starts at 8 AM PST\, 4 PM GMT\, and 11 AM EST. \nLearn how HALO and HALO AI are helping expand our understanding of immune regulation by different subtypes of cancer-associated fibroblasts!\n\n\n\n\nSummary\n\n\n\n\nCancer-associated fibroblasts (CAFs) shape the tumor microenvironment (TME)\, influencing immune cell (IC) infiltration and anti-tumor activity. Three major CAF subtypes are identified in cutaneous carcinomas. Immunomodulatory CAFs (iCAFs)\, enriched in late-stage tumors\, express cytokines and chemokines that promote IC recruitment and activation. Matrix CAFs (mCAFs) produce extracellular matrix and ensheath tumor nests\, restricting IC entry. Myofibroblast-like CAFs (myoCAFs) resemble pericytes and contractile fibroblasts and likely support tissue remodeling and tumor vasculature.   \nKeratinocyte cancers\, including basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs)\, were profiled by Imaging Mass Cytometry using a panel targeting major myeloid\, lymphoid and CAF subsets\, including activation and exhaustion markers. Image analysis\, clustering\, and spatial mapping were performed with HALO\, Seurat\, and Squidpy\, enabling high-resolution definition of CAF niches.   \nSCCs harbored more immune cells than BCCs\, particularly lymphocytes. Tumor immune phenotypes—immune-desert\, -excluded\, and -inflamed—correlated with CAF composition: inflamed SCCs were enriched in iCAFs\, whereas immune-excluded BCCs and SCCs contained more mCAFs and myoCAFs; infiltrative BCCs were particularly enriched in myoCAFs. Spatial analysis mapped iCAFs adjacent to lymphocytes\, while myoCAFs formed fibroblast-rich stromal regions largely devoid of immune cells. These findings indicate that specific CAF subtypes differentially regulate immune infiltration and activation\, suggesting that targeting specific CAF subsets could enhance immunotherapy efficacy in cutaneous keratinocyte carcinomas and could be possibly translated to other keratinocyte cancers.  \n\n\n\n\n\n\n\n\nLearning Objectives\n\n\n\n\n\nLearn how to analyze highly multiplexed stainings in HALO \nLearn about the workflow applied in the study: Cell segmentation\, tissue classification\, cell phenotyping in R\, import of cell phenotypes back into HALO to conduct quality control and spatial analysis.\nLearn how cancer-associated fibroblast niches influence immune cell activation in skin cancer\n\n\n\n\n\nRegister NowPresenter\nBertram Aschenbrenner\, PhD \nPost-Doctoral Fellow \nLichtenberger Laboratory\, Medical University of Vienna   \nDr. Bertram Aschenbrenner studied molecular biology at the University of Vienna\, Austria and performed his master studies in the laboratory of Manuela Baccarini analyzing CRAF – Rok-α interactions. During his PhD studies in the research group of Ira-Ida Skvortsova at the Medical University of Innsbruck\, he dissected radioresistance mechanisms of mesenchymal breast carcinoma cells.  \nIn his current role as a post-doctoral fellow in the lab of Beate Lichtenberger at the Medical University of Vienna\, Bertram uses imaging mass cytometry\, 2D and 3D cell culture systems\, and skin cancer organoids harboring native tumor stroma to investigate different immunomodulatory functions of cancer-associated fibroblasts. 
URL:https://www.pathologynews.com/event/highly-multiplexed-imaging-reveals-caf-immune-cell-niches-in-cutaneous-carcinomas/
LOCATION:Online
CATEGORIES:Live Online Webinar
ATTACH;FMTTYPE=image/jpeg:https://www.pathologynews.com/wp-content/uploads/2025/12/Feature-image_800x600.jpg
END:VEVENT
END:VCALENDAR