Increasing objectivity in tissue analysis
Lumito has developed the next-generation tissue analysis system, based on upconverting nanoparticles (UCNPs). Lumito SCIZYS is a cutting-edge, high-sensitivity system combining labeling and imaging technologies to locate and measure biomarkers in tissue samples.
The company holds a broad patent portfolio. Lumito’s solution enables quantitative and objective assessment of tissue samples, addressing a multitude of challenges in drug development and academic research.
Key Benefits
Ultra-sensitive detection
Detection of single labels from photon-upconverting nanoparticles
- Ultra-sensitive detection of labels down to single upconverting nanoparticles
- Wide dynamic range system, detection of ultra-low and high signal in the same data set
- No degradation of signal over time
- No autofluorescence
Detection of single photon-upconverting nanoparticle labels
The same image can be viewed in brightfield, UCNP-mode or combined
Full biomarker and morphology separation
Chromogenic counterstain and biomarker information in fully separated channels from the same sample
- No need for consecutive tissue sections
- No autofluorescence
- Biomarker expressions can be directly linked to cell morphology
Exceptional dynamic range
High-accuracy quantification based on uniform nanoparticle light quanta and a wide dynamic range detection system
- Quantitative data instead of visual classification
- Reliable cross sample comparisons
- Wide dynamic range allows analysis of a single image with biomarker expressions ranging from ultra-low to high
SCIZYS system measures across a wide dynamic range with excellent precision
Application Areas
Lumito’s technology addresses challenges in several application areas, which can be divided into three main groups:
- Drug development
- Academic research
- Clinical diagnostics*
In these areas, existing methods for tissue analysis have gaps in relation to sensitivity and precise quantification, gaps that are bridged with the Lumito SCIZYS system. The SCIZYS system thus allows for a higher degree of objectivity in judgments and decision-making.
* Lumito’s platform is not approved for clinical use and assessment of patient results for diagnostic purposes is not an approved application.
An Open Immunochemistry System
The Lumito SCIZYS system is an open platform for immunohistochemistry (IHC). The SCIZYS UCNPs can be attached to any biotinylated molecule and the system is agnostic to tissue type, enabling a wide range of uses. We are co-developing application areas together with our customers and partners. Areas with significant interest and potential include:
- Detection of rare cells
- Detection of HER2 low/ultralow
- Optimising cut points for patient stratification for the next generation of ADCs
- Quantitative displacement experiments in development of ADCs
- Measuring subtle changes in pre-clinical models for degenerative diseases where traditional IHC images appear saturated
- Tissue Cross Reactivity studies
- Replacing visual categorization with quantitative analysis during drug development
- Algorithmic quantification of specific biomarkers, using morphology and biomarker expression from different channels in the same sample
- A very sensitive and stable label complementing multiplexed immunofluorescence studies
- Virtual annotations in development of immunohistochemistry AI applications
