Ultivue – Assay Development

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Ultivue offers multiplex IF services through its proprietary InSituPlex® DNA-barcoding and antibody staining technology.

 

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Product Description

Let us support you in investigating your novel hypothesis by obtaining the most informative data from your valuable samples using our InSituPlex® technology and whole slide imaging (WSI). In partnership with our team of Histopathology experts, we will help advance your specific research needs.

Why Tissue Plex with InSituPlex®?

highly customizable solutions and scientific consultative approach strengthen and accelerate biomarker discovery and drug development programs.

InSituPlex® technology requires only a single antigen retrieval step before applying a mixture of DNA barcoded antibodies, which then bind to the desired array of antigens. After amplification, fluorescent probes are attached to those barcodes, allowing for visualisation of the model using fluorescent microscopy. The InSituPlex technology is available in 4, 8, 12-plex panel options.

Ultivue - Assay Development
Ultivue - Assay Development
Ultivue - Assay Development
Ultivue - Assay Development

Why Tissue Plex with InSituPlex®?

highly customizable solutions and scientific consultative approach strengthen and accelerate biomarker discovery and drug development programs.

InSituPlex® technology requires only a single antigen retrieval step before applying a mixture of DNA barcoded antibodies, which then bind to the desired array of antigens. After amplification, fluorescent probes are attached to those barcodes, allowing for visualisation of the model using fluorescent microscopy. The InSituPlex technology is available in 4, 8, 12-plex panel options.

Ultive - Assay Development

H&E staining and mIF on one slide.

Instead of staining and assessing just one or two protein biomarkers
at a time or even multiple markers throughout a set of serial sections.

InSituPlex® technology allows for multiple Biomarkers coupled to
traditional H&E staining to be visualized and quantified using just
a single tissue slide.

 

Multiple Antibodies.

Up to twelve different antibodies can be added at the same time.
Only one single staining step is required, eliminating the need for
secondary antibodies.

Partner with our team of ground-breaking experts

A collaborative partnership for your assay development.

With In-house expertise in both IHC and multiplex immunofluorescence (mIF) assay development, customers can expect a unique experience with the Ultivue service team. Working in an agile and collaborative environment, get quick custom assay development and optimization.

Scientific expertise from start to finish.

The same expert IHC scientists are involved throughout the entire length of a project ensuring consistency from project inception all the way to delivery of the results.

CLIA-certified lab.

Ultivue is a CLIA-certified lab, ensuring regulatory compliance and data integrity for your projects. Rest assured that you will receive accurate, reliable, and timely test results.

Moritz Widmaier, PhD
Florian Leiss, PhD
Lorenz Rognoni, PhD
Ultivue - Digital Pathology

Customized image analysis

Evaluate spatial relationships
Look at cell clustering, dispersion and co-localization
Find immune excluded regions and much more
Compare biomarker profiles
Confirm differences between groups within the data set
Look at the effects of different treatment plans over time

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