The following abstract is drawn from a recently published paper in Journal of Pathology Informatics. We invite you to read the full paper and join the conversation, become a member of the Pathology News community to share your thoughts, ask questions, and engage with others around this work.
Authors: Manu Sebastiana, Harsh Batrab, Monika Lamba Sainic, Staci Kearneyd, Lorcan Sherrye, Serge Alexanianf, Michael Coheng, William Weberh, Joe Lennerzi, Anil V. Parwanij
Abstract
This is a comprehensive review on current utilization and challenges of digital pathology adoption in clinical trials and aims to provide a broad view on its impact on pathology review processes in clinical trials. It provides an overview of current pathology review practices in clinical trials and unique advantages digital pathology adoption can offer. The key areas including existing workflows, use case scenarios in different disease areas in clinical trials, including but not limited to patient identification and pre-screening, and regulatory aspects have been described with relevance. In addition, the review delves into the integration of genomics, AI, image analysis, radiology, and advanced computational pathology, to propose measures to enhance clinical trial outcomes. The current regulatory landscape around digital pathology adoption and potential future advancements in this field are also discussed as appropriate.
Read the Full Article: Applications and challenges of utilizing digital pathology and AI-enabled workflows in clinical trials – ScienceDirect
- aThe University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States of America
- bUniversity Health Networks, Toronto M5G2C4, Canada
- cADC Therapeutics, Imperial College, White City Campus, London W12 0BZ, UK
- dElevation Strategic Development, 7314 Rossman Gulch Rd, Morrison, CO 8046, United States of America
- eOracleBio Limited, Biocity Scotland, North Lanarkshire ML1 5UH, UK
- f11390 W Olympic Blvd STE 250, Los Angeles, CA 90064, United States of America
- gWake Forest University School of Medicine, Bowman Gray Center for Medical Education, 475 Vine Street, Winston-Salem, NC 27101, United States of America
- hTakeda, 650 E Kendall St, Cambridge, MA 02142, United States of America
- iBostonGene, University Office Park III, 95 Sawyer Road, Waltham, MA 02453, United States of America
- jWexner Medical Center, Ohio State University, 410 W 10th Ave, Columbus, OH 43210, United States of America
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