The Tissue Image Analytics (TIA) Centre hosts a seminar series for those interested in computational pathology. The series invites researchers and leaders in computational pathology and related fields to present their work and foster thought-provoking discussions.

This seminar features Dr Matthew Pugh from University of Birmingham, Birmingham, UK.

Abstract

Multiomic spatial profiling technologies are transforming primary tissue research, yielding exciting new biological insights into disease processes. Despite this, the benefits of this technology in clinical practice have not yet been realised. The diagnosis of blood cancer depends heavily on tissue biopsy histological assessment, necessitating multiple immunohistochemical and in-situ hybridisation assays, performed on separate tissue sections. This tissue-intensive approach can lead to tissue exhaustion and a repeat biopsy procedure. Multiomic spatial profiling techniques enable all these assays to  be performed on a single section of tissue, facilitating complete diagnosis and streamlining laboratory and diagnostic processes. Computational and artificial intelligence-driven analysis of this data could facilitate pathological diagnosis and generate novel predictive and diagnostic biomarkers. In this talk we will explore the benefits and risks that multiomic spatial profiling combined with computational pathology could bring to the field of diagnostic haematopathology.

Bio

Dr Pugh is an associate clinical professor and an honorary consultant haematopathologist based at the University of Birmingham. Following a BRC Molecular Pathology Fellowship at the ICR, London, and JSPS and BHP pre-doctoral fellowships, he was awarded an MRC CRTF. Dr Pugh now leads a group researching EBV-driven lymphoproliferations, specialising in the use of spatial profiling techniques to transform our understanding of lymphoproliferative disorders, improve diagnosis, and inform treatment.