The Mount Sinai Tisch Cancer Center (TCC) has launched a new artificial intelligence (AI) platform to help connect more cancer patients across the Mount Sinai Health System to life-saving clinical trials. The platform, which was created by the AI company Triomics, is called PRISM, and is powered by Triomics’ OncoLLM, a large language model-based pipeline built especially for cancer care. As an early adopter of this new technology, Mount Sinai becomes the first National Cancer Institute (NCI)-designated Comprehensive Cancer Center in New York City to deploy this oncology-specific AI tool for systemwide clinical trial matching.
The deployment marks a major step forward in expanding access to innovative cancer research, accelerating clinical trial enrollment, and ensuring patients across the Health System are considered for cutting-edge treatment options earlier in their care.
“Clinical trials are essential to advancing cancer care, but too often patients and their treating physicians are not aware of studies that may be appropriate for them,” said Karyn Goodman, MD, MS, Professor and Vice Chair of Clinical Research in the Department of Radiation Oncology at the Icahn School of Medicine at Mount Sinai and Associate Director of Clinical Research at TCC. “By deploying an AI platform trained specifically for oncology, we can identify trial opportunities earlier, more consistently, and more equitably, allowing clinicians to focus on meaningful conversations with patients rather than manual chart review.”
Clinical trial matching is the process of determining which research studies a patient may be eligible for based on their electronic health records, diagnosis, medical history, and specific clinical characteristics. Traditionally, this work has relied on manual review of lengthy trial protocols and fragmented medical records, a time-intensive process that can sometimes delay or limit patient access to promising new therapies.
Historically, trial participation has been concentrated at flagship academic sites. With systemwide deployment, patients seen at Mount Sinai Queens, Mount Sinai Brooklyn, Mount Sinai South Nassau, Mount Sinai Morningside, Mount Sinai West, and other sites have the same accessibility to available trials as those treated at The Mount Sinai Hospital.
This initiative directly advances Mount Sinai’s mission as an NCI-designated Comprehensive Cancer Center, strengthening systemwide access to clinical trials, accelerating research integration across care settings, and supporting improved outcomes for the diverse communities it serves. By expanding the pool of patients who can be considered for research at the right moment in their care, Mount Sinai is positioned to meet, and potentially exceed, national benchmarks for trial participation.
The successful deployment reflects close collaboration among Triomics, TCC, and Mount Sinai Research IT, combining technical innovation, clinical leadership, and robust governance to bring clinical trials closer to the bedside. Mount Sinai plans to evaluate outcomes from this deployment and share findings through future peer-reviewed publications and national scientific meetings.
For more Mount Sinai artificial intelligence news, visit: https://icahn.mssm.edu/about/artificial-intelligence.
About the Icahn School of Medicine at Mount Sinai
The Icahn School of Medicine at Mount Sinai is internationally renowned for its outstanding research, educational, and clinical care programs. It is the sole academic partner for the seven member hospitals* of the Mount Sinai Health System, one of the largest academic health systems in the United States, providing care to New York City’s large and diverse patient population.
The Icahn School of Medicine at Mount Sinai offers highly competitive MD, PhD, MD-PhD, and master’s degree programs, with enrollment of more than 1,200 students. It has the largest graduate medical education program in the country, with more than 2,600 clinical residents and fellows training throughout the Health System. Its Graduate School of Biomedical Sciences offers 13 degree-granting programs, conducts innovative basic and translational research, and trains more than 560 postdoctoral research fellows.
Ranked 11th nationwide in National Institutes of Health (NIH) funding, the Icahn School of Medicine at Mount Sinai is among the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. More than 4,500 scientists, educators, and clinicians work within and across dozens of academic departments and multidisciplinary institutes with an emphasis on translational research and therapeutics. Through Mount Sinai Innovation Partners (MSIP), the Health System facilitates the real-world application and commercialization of medical breakthroughs made at Mount Sinai.
* Mount Sinai Health System member hospitals: The Mount Sinai Hospital; Mount Sinai Brooklyn; Mount Sinai Morningside; Mount Sinai Queens; Mount Sinai South Nassau; Mount Sinai West; and New York Eye and Ear Infirmary of Mount Sinai.
About the Mount Sinai Health System
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with 48,000 employees working across seven hospitals, more than 400 outpatient practices, more than 600 research and clinical labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time—discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.
Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 9,000 primary and specialty care physicians and 10 free-standing joint-venture centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida. Hospitals within the System are consistently ranked by Newsweek’s® “The World’s Best Smart Hospitals, Best in State Hospitals, World Best Hospitals and Best Specialty Hospitals” and by U.S. News & World Report‘s® “Best Hospitals” and “Best Children’s Hospitals.” The Mount Sinai Hospital is on the U.S. News & World Report® “Best Hospitals” Honor Roll for 2025-2026.
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