The integration of informatics into pathology is rapidly transforming the field, with the potential to enhance diagnostic accuracy, streamline workflows, and improve patient outcomes. Digital pathology (DP), artificial intelligence (AI), and machine learning are among the innovations revolutionizing traditional practices by enabling the digitization of tissue samples, the automation of data analysis, and the incorporation of large datasets into diagnostic processes. Whereas these advancements hold great promise, they have also generated mixed reactions among healthcare professionals, particularly in pathology, where the balance between human expertise and technology is critical. To better understand the perceptions of informatics in pathology, a cross-sectional survey was conducted among healthcare workers within the field. The survey aimed to assess attitudes toward the adoption of informatics, with specific focus on its perceived benefits and challenges. This study seeks to provide insights into how these new technologies are being received by those at the forefront of pathology, exploring both the enthusiasm and apprehension surrounding the growing role of informatics in the discipline.